PHYSICOMECHANICAL AND COMPACTION CHARACTERIZATION OF TABLETS OBTAINED FROM A DRY NATURAL EXTRACTS

  • MSc. Jesús Rafael Rodríguez-Amado Department of Pharmacy, University of Orient, Santiago of Cuba
  • MSc. Ariadna LafourcadePrada Department of Pharmacy, University of Orient, Santiago of Cuba
  • MSc. Julio Cesar Escalona-Arranz Department of Pharmacy, University of Orient, Santiago of Cuba
  • MSc. Renato Pérez- Rosés Department of Pharmacy, University of Orient, Santiago of Cuba
  • Phd. Antonio Iraizoz-Colarte Department of Pharmacy, University of Orient, Santiago of Cuba
DOI: https://doi.org/10.1590/2224-6185.2011.2.%25x
Keywords: tamarind, dry extract, Heckel analysis, compression, tablets

Abstract

The aim of this work was to evaluate the compaction behavior and the physical mechanical characterization of tablets, obtained from a natural dry extracts of the leaves of Tamarindus indica L. The Heckel analysis was used to characterize the dry extract compaction behavior. The dry extract has a mixed mechanism of consolidation: plastic and brittle fracture, showing a mean yield
pressure of 179,85 MPa. The compact’s tensile strength increase with the augment of compaction pressure. Compacts must be obtained at compaction pressure below 90MPa because of; at superior compaction pressure disintegration time increases over 30 min. The friability of the tablets in any case is superior to 1 percent.
Published
2016-03-01
How to Cite
Rodríguez-Amado, M. J. R., LafourcadePrada, M. A., Escalona-Arranz, M. J. C., Pérez- Rosés, M. R., & Iraizoz-Colarte, P. A. (2016). PHYSICOMECHANICAL AND COMPACTION CHARACTERIZATION OF TABLETS OBTAINED FROM A DRY NATURAL EXTRACTS. Chemical Technology, 31(2), 75-81. https://doi.org/10.1590/2224-6185.2011.2.%x
Issue
Vol 31 No 2 (2011)
Section
Artículos

This work is licensed under the Creative Commons Attribution-NonCommercial.